TABLE 3.

Summary of the pharmacokinetic measures for rifampicin, by formulation regulatory status

Batch and parameter2-h level (mg · liter−1)Tmax (h)Cmax (mg · liter−1)t1/2 (h)AUC0-8 (mg · h · liter−1)AUC0-∞ (mg · h · liter−1)
Approved batches
    No. of patients888888838783
    Median4.42.55.91.921.525.6
    Interquartile range2.1-6.72.0-3.04.2-8.41.5-2.515.3-31.716.6-36.0
    Minimum-maximum0-14.81.0-8.01.3-14.90.9-4.73.6-65.85.6-80.1
Nonapproved batches
    No. of patients544954425442
    Median2.12.53.81.813.718.9
    Interquartile range0.0-5.32.0-3.01.3-6.71.6-2.34.6-26.012.1-31.4
    Minimum-maximum0.0-20.41.0-8.10.0-20.41.0-6.80.0-81.64.0-102.7