TABLE 3.

MICs of macrolides and related antibiotics for ribosomal mutants of clinical isolates of S. pneumoniae

ProductMutationNo. of isolatesMIC (μg/ml) ofa:Reference(s)
AZMCLRERYSPIJOSTELQUIPRI or Q-DCLI
23S rRNA domain V (no. of mutated copies)A2059G (2 or 3)5>100->51212.5->51250->100512>1000.01-0.253.12-322-40.78-229, 41
A2059C (2 to 4)7128-512512->512256->512512->512ND0.06-0.1216-321-21-229
A2062C (4)10.5ND<0.2551264<0.0075322<0.01510
C2611G (4)1128>512>51216ND0.5>642129
L4 protein69TPS7117>100->51212.5->512>100->512641000.03-0.212.5-2520.05-0.229, 41
Insertion (71GREKGTGR72)b112.512.56.25ND6.253.1225ND0.0541
L22 proteinDuplication (102KRTAHITRTAHITVA116)b1>1ND>1NDNDNDND>1ND25
  • a QUI, quinupristin; Q-D, quinupristin-dalfopristin; see Table 2, footnote b, for other definitions.

  • b The mutation is underlined.