TABLE 3

ED50s of different anti-Toxoplasma drugs in vivo

CompoundED50 (range) in mice (mg/kg/day)a
C7S0.87 (0.77–0.89)
Risedronate0.22 (0.12–0.68)
Atorvastatin32.4 (14.1–70.4)
Zoledronate0.25 (0.17–0.51)
Atovaquone2.53 (1.82–4.17)
  • a The drugs were administered i.p. to groups of 5 mice during 10 days, and the results are expressed as the ED50 values calculated from the results of all experiments combined; the ranges of ED50s are calculated from the results of each of the three to four independent experiments using each drug.