TABLE 1

Biological activities of C7S and other bisphosphonates against T. gondii tachyzoites, TgFPPS, and HsFPPSa

CompoundMean T. gondii EC50 ± SD (μM)Mean IC50 ± SD (μM) for:
TgFPPSHsFPPS
C7S1.49 ± 0.380.03 ± 0.0001.31 ± 0.53
Risedronate2.40 ± 0.70.44 ± 0.010.40 ± 0.01
Zoledronate0.84 ± 0.040.07 ± 0.020.43 ± 0.04
Alendronate32.880.14 ± 0.055.13 ± 1.77
Atovaquone0.032 ± 0.019NDND
  • a Results are expressed as mean values ± SD from three independent experiments except for growth with alendronate, which has very low in vitro activity. ND, not determined.