TABLE 1.

In vitro activities of tigecycline and comparators

Organism (no. of strains) and antimicrobial agentMIC (μg/ml)
Range50%90%
Staphylococcus aureus, methicillin     susceptible (121)
    Tigecycline0.06-0.50.120.25
    Minocycline0.03-80.120.25
    Oxacillin0.06-20.51
    Ceftriaxone1-824
    Vancomycin0.5-211
    Quinupristin-dalfopristin0.12-10.250.5
    Linezolid1-424
    Gatifloxacin0.03-80.060.06
Staphylococcus aureus, methicillin     resistant (51)
    Tigecycline0.12-10.250.25
    Minocycline0.06-1648
    Oxacillin4->16>16>16
    Ceftriaxone4->32>32>32
    Vancomycin0.5-211
    Quinupristin-dalfopristin0.25-10.51
    Linezolid1-424
    Gatifloxacin0.06-824
Staphylococcus epidermidis (85)
    Tigecycline0.06-10.250.5
    Minocycline0.06-20.250.5
    Oxacillin0.06->164>16
    Ceftriaxone0.12->32432
    Vancomycin0.5-212
    Quinupristin-dalfopristin0.12-20.250.25
    Linezolid0.25-411
    Gatifloxacin0.06-40.122
Staphylococcus haemolyticus (45)
    Tigecycline0.06-20.51
    Minocycline0.03-40.251
    Oxacillin0.5->16>16>16
    Ceftriaxone4->32>32>32
    Vancomycin0.5-412
    Quinupristin-dalfopristin0.12-20.250.5
    Linezolid0.5-212
    Gatifloxacin0.06-1648
Enterococcus faecalis (124)
    Tigecycline≤0.015-10.120.25
    Minocycline0.03->32816
    Oxacillin8->16>16>16
    Ceftriaxone8->32>32>32
    Vancomycin0.5->12812
    Quinupristin-dalfopristin0.25->32832
    Linezolid1-422
    Gatifloxacin0.12->160.516
Enterococcus faecium (114)
    Tigecycline0.03-0.250.060.12
    Minocycline0.06-321616
    Oxacillin4->16>16>16
    Ceftriaxone4->32>32>32
    Vancomycin0.25->1281>128
    Quinupristin-dalfopristin0.25-3214
    Linezolid1-422
    Gatifloxacin0.12->164>16
Group A streptococci (135)
    Tigecycline≤0.015-0.50.60.6
    Minocycline0.03-160.068
    Oxacillin≤0.03-0.250.060.06
    Ceftriaxone≤0.015-0.06≤0.0150.03
    Vancomycin0.25-10.50.5
    Quinupristin-dalfopristin0.12-10.120.25
    Linezolid0.5-211
    Gatifloxacin0.12-20.250.5
Group B streptococci (23)
    Tigecycline0.03-0.060.060.06
    Minocycline0.06-161616
    Oxacillin0.25-0.50.50.5
    Ceftriaxone0.06-0.120.060.12
    Vancomycin0.5-0.50.50.5
    Quinupristin-dalfopristin0.25-10.250.5
    Linezolid1-212
    Gatifloxacin0.12-0.50.250.5
Streptococcus pneumoniae,     penicillin susceptible (107)
    Tigecycline≤0.015-10.030.25
    Minocycline0.03-160.120.5
    Oxacillin≤0.03-2≤0.030.25
    Ceftriaxone≤0.015-0.25≤0.0150.03
    Vancomycin0.12-0.50.50.5
    Quinupristin-dalfopristin0.25-10.51
    Linezolid0.25-111
    Gatifloxacin0.06-0.50.250.5
Streptococcus pneumoniae,     penicillin intermediate (26)
    Tigecycline0.03-10.060.5
    Minocycline0.06-320.516
    Oxacillin≤0.03-16216
    Ceftriaxone≤0.015-10.121
    Vancomycin0.06-0.50.250.5
    Quinupristin-dalfopristin0.25-10.51
    Linezolid0.25-111
    Gatifloxacin0.12-0.50.250.25
Streptococcus pneumoniae,     penicillin resistant (17)
    Tigecycline0.03-10.120.5
    Minocycline0.06-160.2516
    Oxacillin0.5->1616>16
    Ceftriaxone0.25-211
    Vancomycin0.25-0.50.250.5
    Quinupristin-dalfopristin0.25-10.51
    Linezolid0.25-111
    Gatifloxacin0.12-10.250.5
Viridans group streptococci (86)
    Tigecycline≤0.015-20.120.5
    Minocycline0.06-320.516
    Oxacillin≤0.03->160.252
    Ceftriaxone≤0.015-80.121
    Vancomycin≤0.06-10.51
    Quinupristin-dalfopristin0.12-211
    Linezolid0.5-211
    Gatifloxacin0.12-20.250.5
Escherichia coli (100)
    Tigecycline0.06-10.250.5
    Minocycline0.25-6418
    Piperacillin0.5->128128>128
    Piperacillin-tazobactam0.25->12824
    Ceftriaxone≤0.06-4≤0.06≤0.06
    Imipenem≤0.06-20.120.25
    Gatifloxacin≤0.008-160.030.5
    Tobramycin0.25-812
Klebsiella pneumoniae (101)
    Tigecycline0.25-40.51
    Minocycline1->64232
    Piperacillin2->12816>128
    Piperacillin-tazobactam0.5->128416
    Ceftriaxone≤0.06->128≤0.0632
    Imipenem0.12-20.250.5
    Gatifloxacin0.03-160.061
    Tobramycin0.12->320.516
Klebsiella oxytoca (49)
    Tigecycline0.5-20.51
    Minocycline1->6428
    Piperacillin2->12816>128
    Piperacillin-tazobactam1->1282>128
    Ceftriaxone≤0.06-1280.1232
    Imipenem0.12-0.50.250.5
    Gatifloxacin0.03-40.060.5
    Tobramycin0.25->320.5>32
Proteus mirabilis (88)
    Tigecycline1-848
    Minocycline4->6464>64
    Piperacillin0.12->1280.5>128
    Piperacillin-tazobactam≤0.06-1280.51
    Ceftriaxone≤0.06-64≤0.06≤0.06
    Imipenem0.5-848
    Gatifloxacin0.12->160.258
    Tobramycin0.25->3228
Proteus vulgaris (30)
    Tigecycline0.12-1644
    Minocycline0.5->64864
    Piperacillin0.25->1281>128
    Piperacillin-tazobactam0.12-20.251
    Ceftriaxone≤0.06-64≤0.064
    Imipenem0.25-444
    Gatifloxacin0.03-160.120.25
    Tobramycin0.5-412
Serratia marcescens (61)
    Tigecycline0.5-424
    Minocycline2-32416
    Piperacillin1->1284>128
    Piperacillin-tazobactam0.5->128232
    Ceftriaxone≤0.06->1280.2516
    Imipenem0.5-822
    Gatifloxacin0.06->160.254
    Tobramycin0.5->32216
Enterobacter cloacae (81)
    Tigecycline0.25-412
    Minocycline2-3248
    Piperacillin0.5->1284>128
    Piperacillin-tazobactam1->1282128
    Ceftriaxone≤0.06->1280.25>128
    Imipenem0.12-20.51
    Gatifloxacin0.015-160.060.25
    Tobramycin0.25-320.51
Enterobacter aerogenes (42)
    Tigecycline0.25-812
    Minocycline1-64416
    Piperacillin2->128128>128
    Piperacillin-tazobactam1->12816128
    Ceftriaxone≤0.06->128864
    Imipenem0.25-212
    Gatifloxacin0.03->160.12>16
    Tobramycin0.25-32116
Citrobacter freundii (41)
    Tigecycline0.25-160.52
    Minocycline1->64432
    Piperacillin1->1284>128
    Piperacillin-tazobactam1->128464
    Ceftriaxone≤0.06->1280.5128
    Imipenem0.25-412
    Gatifloxacin0.015->160.062
    Tobramycin0.25-320.516
Morganella morganii (34)
    Tigecycline1-824
    Minocycline2->64864
    Piperacillin0.25->128164
    Piperacillin-tazobactam0.12->1280.250.5
    Ceftriaxone≤0.06-128≤0.060.5
    Imipenem2-444
    Gatifloxacin0.03-160.122
    Tobramycin0.25-40.52
Pseudomonas aeruginosa (50)
    Tigecycline0.5-321632
    Minocycline2->641632
    Piperacillin2->12816>128
    Piperacillin-tazobactam0.25->1288>128
    Ceftriaxone8->128128>128
    Imipenem0.25->128232
    Gatifloxacin0.25->161>16
    Tobramycin0.25->321>32
Acinetobacter spp. (50)
    Tigecycline0.06-40.252
    Minocycline≤0.03-160.128
    Piperacillin1->12832>128
    Piperacillin-tazobactam≤0.06->12816>128
    Ceftriaxone0.12->12816>128
    Imipenem≤0.06->1280.532
    Gatifloxacin0.03-160.1216
    Tobramycin0.12->32132
Stenotrophomonas maltophilia     (39)
    Tigecycline0.25-40.52
    Minocycline0.12-10.250.5
    Piperacillin8->128>128>128
    Piperacillin-tazobactam8->128>128>128
    Ceftriaxone32->128>128>128
    Imipenem32->128>128>128
    Gatifloxacin0.12-40.52
    Tobramycin1->3232>32
Burkholderia cepacia (20)
    Tigecycline0.5-64432
    Minocycline1-64216
    Piperacillin2->1288128
    Piperacillin-tazobactam1->128464
    Ceftriaxone0.5->1284>128
    Imipenem0.25-32832
    Gatifloxacin0.25->162>16
    Tobramycin8->32>32>32
Haemophilus influenzae (103)
    Tigecycline0.12-20.51
    Minocycline0.12-20.51
    Piperacillin≤0.06-64≤0.060.25
    Piperacillin-tazobactam≤0.06-0.5≤0.06≤0.06
    Ceftriaxone≤0.06-0.12≤0.06≤0.06
    Imipenem≤0.06-20.51
    Gatifloxacin≤0.008-0.06≤0.0080.015
    Tobramycin0.5-824
Moraxella catarrhalis (101)
    Tigecycline≤0.03-0.250.060.12
    Minocycline≤0.03-10.060.12
    Piperacillin≤0.06-160.54
    Piperacillin-tazobactam≤0.06-≤0.06≤0.06≤0.06
    Ceftriaxone≤0.06-1≤0.060.5
    Imipenem≤0.06-0.5≤0.060.12
    Gatifloxacin≤0.008-0.250.030.03
    Tobramycin≤0.06-0.250.120.25