TABLE 1.

Susceptibilities of S. prolificans strains against various azoles alone and in combination with terbinafinea

Combination and strainGM MIC-1 (range)
Drug aloneDrugs in combination
AzoleTBAzoleTB
VCZ and TB
    78989.51 (8-16)>64 (>64)0.71 (0.13-2)9.51 (2-32)
    79016.73 (4-8)>64 (>64)0.25 (0.03-1)6.73 (4-16)
    79026.73 (4-8)>64 (>64)0.5 (0.13-1)8 (8)
    79068 (8)>64 (>64)1 (0.5-2)9.51 (8-16)
    79189.51 (8-16)>64 (>64)1.19 (0.5-2)11.31 (2-32)
MCZ and TB
    789864 (32->64)>64 (>64)1.19 (0.25-4)2.83 (2-4)
    7901>64 (>64)>64 (>64)2.83 (2-4)2 (1-4)
    790245.25 (8->64)>64 (>64)2 (0.13-8)2 (2)
    7906>64 (>64)>64 (>64)2.83 (2-4)1.41 (1-4)
    791826.91 (8->64)>64 (>64)0.84 (0.13-2)2.38 (2-4)
ICZ and TB
    7898>32 (>32)>64 (>64)1 (0.5-2)16 (16)
    7901>32 (>32)>64 (64->64)10.01 (4-16)12.7 (8-16)
    7902>32 (>32)>64 (64->64)4 (0.5-16)8 (8)
    7906>32 (>32)>64 (>64)3.17 (1-16)8 (2-16)
    7918>32 (>32)>64 (>64)4 (1-16)10.08 (2-16)
  • a Based on the MIC-1 and SP72 data. Abbreviations: VCZ, voriconazole; MCZ, miconazole; ICZ, itraconazole; TB, terbinafine.