TABLE 3.

Summary of posaconazole pharmacokinetic data on last study day (n = 28)

Group (no. of patients)Mean last day (SD)Cmax (SD) (ng/ml)Tmax (SD) (h)AUC0-24 (SD) (mg ยท h/liter)CL/F (SD) (ml/min)
MeanMedianRange
I (7)14 (6.0)263 (202)3.9 (1.7)4.01-64.5 (2.9)990.8 (516.7)
II (14)9.9 (2.3)351.7 (165.8)6.9 (3.1)73-126.4 (3.2)1,506.7 (1201.7)
III (7)8.1 (1.1)478.9 (194.2)10.3 (10)10.31-248.7 (3.3)1,485.5 (873.5)