Comparative in vitro activities of posaconazole, itraconazole, fluconazole, voriconazole, and amphotericin B against isolates of Candida spp. and Cryptococcus spp.

OrganismNo. of MICsMIC (μg/ml)a
All Candida spp.6,9650.0631.00.1251.00.516.00.0310.51.0b1.0b
    C. albicans3,5350.0310.0630.0630.
    C. glabrata1,2181.
    C. parapsilosis9700.0630.
    C. tropicalis7190.0630.250.1250.
    C. krusei1890.
    C. lusitaniae840.0630.
    C. guilliermondii260.
    C. dubliniensis1640.0310.1250.0630.50.2532.00.0160.1250.51.0
    Other Candida spp.c600.
Cryptococcus spp.d2710.1250.250.1250.
  • a 50% and 90%, MIC50 and MIC90, respectively.

  • b The number of strains of C. albicans and C. glabrata tested against AMB was slightly less (for all Candida spp., n = 6,921; for C. albicans, n = 3,517; and for C. glabrata, n = 1,192).

  • c Includes strains of C. famata, C. kefyr, C. lipolytica, C. pelliculosa, C. pseudotropicalis, C. rugosa, C. sphaerica, C. stellatoidea, and C. zeylanoides.

  • d Includes strains of C. laurentii and C. neoformans.