TABLE 3.

Time-kill analyses of 10 H. influenzae strains

Drug and concnNo. of strains testedNo. of strains killed at time pointa:
3 h6 h12 h24 h
−1−2−3−1−2−3−1−2−3−1−2−3
Ceftobiprole10
    4× MIC200104010105101010
    2× MIC20010301084101010
    MIC20092010641097
Amoxicillinb4
    4× MIC100400431443
    2× MIC100300421442
    MIC100300411442
Amoxicillin-clavulanate10
    4× MIC500102010103101010
    2× MIC30010201083101010
    MIC30072010721098
Ceftriaxone10
    4× MIC300104010104101010
    2× MIC30094010104101010
    MIC20092010721097
Cefpodoxime10
    4× MIC40092010103101010
    2× MIC1008201083101010
    MIC1007108511087
Azithromycin10
    4× MIC9411084101010101010
    2× MIC83197310109101010
    MIC510642874996
Telithromycin10
    4× MIC8208621086101010
    2× MIC5108411074101010
    MIC3003301043867
Moxifloxacin10
    4× MIC1082109610109101010
    2× MIC1041108310107101010
    MIC520941108310109
Tetracycline10
    4× MIC510950996999
    2× MIC500820994996
    MIC300410831854
  • a −1, 90% killing; −2, 99% killing; −3, 99.9% killing.

  • b Six H. influenzae strains with amoxicillin MICs of >32 μg/ml were not tested.