TABLE 1.

In vitro activities of selected antimicrobial agents against 321 H. influenzae and 49 M. catarrhalis strains

Antimicrobial agentMIC (μg/ml)
Haemophilus influenzaeMoraxella catarrhalis
β-Lactamase positive (n = 262)β-Lactamase negative (n = 40)BLNAR (n = 19)β-Lactamase positive (n = 40)β-Lactamase negative (n = 9)
RangeMIC50MIC90RangeMIC50MIC90RangeMIC50MIC90RangeMIC50MIC90RangeMIC50
Ceftobiprole0.015-80.060.250.008-10.030.250.03-20.520.03-10.120.5≤0.004-0.03≤0.004
Amoxicillin4->32>32>320.03->32140.5->324161->32816≤0.015-0.12≤0.015
Amoxicillin- clavulanate0.25-8140.03->32140.5-1688≤0.015-0.50.060.25≤0.015-0.12≤0.015
Ceftriaxone≤0.004-0.5≤0.0040.015≤0.004-0.25≤0.0040.03≤0.004-0.50.120.250.015-20.061≤0.004-0.0150.008
Cefpodoxime0.015-40.060.120.008-80.120.50.12-8240.12-20.510.06-0.120.12
Azithromycin0.12->64120.06->64120.5-414≤0.03-1≤0.030.06≤0.03-0.25≤0.03
Telithromycin0.5-32240.06->64241-828≤0.03-10.120.25≤0.03-10.12
Moxifloxacin≤0.008->0.250.0150.03≤0.008->0.250.0150.12≤0.008->0.250.015>0.250.06->0.250.060.120.06-0.120.12
Tetracycline≤1-8≤1≤1≤1≤1≤1≤1≤1≤1≤1->8≤12≤1-2≤1