Comparative in vitro activities of posaconazole, itraconazole, fluconazole, and voriconazole, against isolates of Candida spp. exhibiting resistance to itraconazole, fluconazole, and voriconazole

Isolates (resistance level)No. of MICsaMIC (μg/ml)b
FLC resistant (MIC, >32 μg/ml)
    All Candida4461.
    C. albicans1670.516.02.032.0128.0256.02.032.0
    C. glabrata1492.
    Other Candida spp.1300.
ITC resistant (MIC, >0.5 μg/ml)
    All Candida1,1511.
    C. albicans1761.
    C. glabrata7191.
    Other Candida spp.2560.
VRC resistant (MIC, >2 μg/ml)
    All Candida2344.
    C. albicans1012.
    C. glabrata884.
    Other Candida spp.452.
With POS MIC of >2 μg/ml
    All Candida1768.
    C. albicans628.
    C. glabrata868.
    Other Candida spp.2816.
  • a The data set is the same as that used in Table 4. There were a total of 6,595 MICs for all four drugs.

  • b 50% and 90%, MIC50 and MIC90, respectively.