TABLE 5.

Comparative in vitro activities of posaconazole, itraconazole, fluconazole, and voriconazole, against isolates of Candida spp. exhibiting resistance to itraconazole, fluconazole, and voriconazole

Isolates (resistance level)No. of MICsaMIC (μg/ml)b
POSITCFLCVRC
50%90%50%90%50%90%50%90%
FLC resistant (MIC, >32 μg/ml)
    All Candida4461.016.02.032.0128.0256.02.032.0
    C. albicans1670.516.02.032.0128.0256.02.032.0
    C. glabrata1492.016.04.016.0256.0256.04.08.0
    Other Candida spp.1300.54.01.032.0128.0128.00.532.0
ITC resistant (MIC, >0.5 μg/ml)
    All Candida1,1511.04.01.016.016.0128.00.54.0
    C. albicans1761.016.04.032.064.0256.02.032.0
    C. glabrata7191.04.01.08.016.0128.00.54.0
    Other Candida spp.2560.52.01.08.032.0128.00.516.0
VRC resistant (MIC, >2 μg/ml)
    All Candida2344.016.08.032.0128.0256.08.032.0
    C. albicans1012.016.08.032.0128.0256.08.032.0
    C. glabrata884.016.016.032.0128.0256.04.016.0
    Other Candida spp.452.032.02.032.0128.0128.032.032.0
With POS MIC of >2 μg/ml
    All Candida1768.032.016.032.0128.0256.04.032.0
    C. albicans628.032.016.032.0128.0256.016.064.0
    C. glabrata868.016.016.032.0128.0256.04.08.0
    Other Candida spp.2816.032.08.032.0128.0128.032.032.0
  • a The data set is the same as that used in Table 4. There were a total of 6,595 MICs for all four drugs.

  • b 50% and 90%, MIC50 and MIC90, respectively.