TABLE 3.

Distribution of FKS1 mutations among C. albicans caspofungin-resistant derivatives

Mutation(s) in FKS1Mutation characterAmino acid change(s)No. (%) of mutants derived from the following parental strain bearing the indicated mutationa:
SC5314M70
T1922CHomozygousF641S0 (0)5 (10)
T1933CHeterozygousS645P20 (57)25 (50)
T1933CHomozygousS645P5 (14)3 (6)
C1934AHeterozygousS645Y0 (0)3 (6)
C1934AHomozygousS645Y9 (26)7 (14)
C1934THeterozygousS645F0 (0)3 (6)
C1934THomozygousS645F1 (3)3 (6)
G1932T C1934GHomozygousL644F S645C0 (0)1 (2)
  • a Relative to a total of 35 mutants derived from strain SC5314 and a total of 50 mutants derived from strain M70.