TABLE 5.

Single nucleotide changes found in daptomycin-nonsusceptible posttherapy clinical isolates

StrainSiteaBase changeAmino acid changeLocus
CB1841366486C→TS295LmprF
CB1851368078C→TL826FmprF
CB16341368078C→TL826FmprF
CB163426121Inserted AbFrameshiftyycG
  • a Location of mutations S. aureus strain MW2 sequence (GenBank accession no. BA000033).

  • b Confirmed in multiple independent PCRs and sequencing reactions.