TABLE 2.

Comparative in vitro activities of posaconazole, itraconazole, voriconazole, and amphotericin B against mold isolates

OrganismNo. of MICsMIC (μg/ml)a
POSITCVRCAMB
50%90%50%90%50%90%50%90%
All molds1,7020.251.00.52.00.252.00.52.0
All hyaline moldsb1,6360.251.00.5c2.0c0.251.00.52.0
All Aspergillus spp.1,4230.1250.50.52.00.250.50.51.0
    A. flavus890.250.50.51.00.51.01.02.0
    A. fumigatus1,1190.1250.50.51.00.250.50.51.0
    A. niger1010.250.51.02.00.52.00.1251.0
    A. terreus220.250.250.50.50.250.52.02.0
    Other Aspergillus spp.d920.1251.00.52.00.251.01.02.0
All zygomycetes860.54.01.032.016.0128.00.252.0
    Rhizopus spp.321.08.04.032.016.0128.01.02.0
    Mucor spp.181.016.02.032.064.0128.00.251.0
    Absidia spp.160.1250.250.1250.516.0128.00.250.5
    Cunninghamella spp.60.031-1.00.031-1.00.125-2.00.125-2.08.0-128.08.0-128.00.125-2.00.125-2.0
    Apophysomyces spp.50.031-4.00.031-4.00.031-8.00.031-8.016.0-128.016.0-128.00.031-4.00.031-4.0
    Saksenaea spp.40.016-2.00.016-2.00.016-0.1250.016-0.1250.5-4.00.5-4.00.063-0.50.063-0.5
    Rhizomucor spp.30.016-0.250.016-0.250.016-0.250.016-0.252.0-16.02.0-16.00.063-0.1250.063-0.125
    Cokeromyces spp.20.25-4.00.25-4.00.25-8.00.25-8.016.0-64.016.0-64.00.125-0.50.125-0.5
All dimorphic fungi1510.0630.250.0310.25NDND0.250.5
    Histoplasma spp.530.0190.250.0190.063NDND0.250.5
    Blastomyces spp.380.0630.1250.0312.0NDND0.1250.5
    Coccidioides spp.250.1250.250.1250.25NDND0.50.5
    Paracoccidioides spp.130.0630.1250.0160.063NDND0.1250.25
    Penicillium marneffei120.0160.0160.0080.063NDND0.54.0
    Sporothrix spp.100.51.00.250.5NDND0.51.0
All Fusarium spp.6716.032.016.0e32.0e16.032.08.032.0
    F. solani3932.032.0NDND16.032.016.032.0
    F. oxysporum122.04.0NDND4.032.08.016.0
    F. moniliforme21.01.0NDND1.01.01.0-4.01.0-4.0
    Other Fusarium spp.f1416.016.0NDND4.016.01.02.0
Agents of chromoblastomycosis, mycetoma, and phaeohyphomycosis2410.2516.01.064.0NDND2.032.0
    Scedosporium prolificans8016.032.064.064.0NDND16.032.0
    Scedosporium apiospermum260.251.01.032.0NDND2.08.0
    Pseudallescheria spp.410.251.00.51.0NDND2.04.0
    Aspergillus nidulans200.0630.250.250.5NDND1.02.0
    Exophiala spp.140.250.50.51.0NDND0.51.0
    Alternaria spp.130.1250.250.51.0NDND0.54.0
    Cladosporium spp.110.06316.00.12516.0NDND1.04.0
    Bipolaris spp.100.0630.1250.0630.25NDND0.250.25
    Otherg260.1250.250.251.0NDND0.51.0
Other moldsh580.250.50.0631.00.250.50.252.0
  • a 50% and 90%, MIC50 and MIC90, respectively. When n is <10, the MICs shown are ranges. ND, not determined.

  • b Includes Aspergillus spp. and Fusarium spp. (MIC data for which are shown below), and other various species, including strains of Acremonium, Basidiomycetes, Bjerkandera, Coprinus, Paecilomyces, Pseudallescheria, and Schizophyllum.

  • c Fewer isolates (n = 1,501) were tested against ITC; therefore, the values for ITC cannot be compared directly.

  • d Includes strains of A. glaucus, A. nidulans, A. oryzae, Aspergillus spp., A. sydowii, A. ustus, and A. versicolor.

  • e Fewer isolates (n = 23) were tested against ITC; therefore, the values for ITC cannot be compared directly.

  • f Unspeciated Fusarium.

  • g Includes strains of Cladophialophora, Curvularia, Exserohilum, Fonsecaea, Pithomyces, Ramichloridium, Ulocladium, and Wangiella.

  • h Includes strains of Acremonium, Basidiomycetes, Bjerkandera, Coprinus, Paecilomyces, Pseudallescheria, Schizophyllum, and Trichophyton.