TABLE 1.

AUC0-240 of killing curves normalized by baseline log10 CFU/mlt = 0

Colistin formAUC0-240/(log10 CFU/mlt = 0) (n = 3)
8.0 mg/liter32 mg/liter
CMS186.3 ± 6.090.4 ± 4.1
Colistina192.8 ± 10.470.0 ± 7.4
  • a Spiked incrementally to achieve the same concentration-time course of colistin observed from hydrolysis of CMS spiked initially at 8.0 mg/liter or 32 mg/liter.