TABLE 1.

Target and actual antifungal pharmacokinetic values

DoseTarget (actual)
Cmax (mg/liter)Cmin (mg/liter)t1/2 (h)AUC0-24 (mg · h/liter)
Amphotericin B1.2 (1.2)0.5 (0.12)24 (12)20 (16)
    0.5 mg/kg every 24 h
    1.0 mg/kg every 24 h2.4 (2.6)1.2 (0.4)24 (11)43 (37)
Fluconazole20 (17)10 (8)24 (18)360 (314)
    400 mg every 24 h
    800 mg every 24 h40 (40)20 (16)24 (18)720 (672)
Voriconazole, 4 mg/kg every 12 h3.5 (3.9)0.8 (0.7)6 (8)51 (57)