TABLE 3.

Median viable CFU recovered from sonicated catheter culturesa

RegimenMedian log10 CFU (range)
C. albicansC. glabrataC. parapsilosis
24 h48 h24 h48 h24 h48 h
Control3.3 (2.7-3.9)4.2 (3.6-4.8)3.1 (2.7-3.5)4.3 (3.7-4.9)3.3 (2.8-3.8)3.1 (2.7-3.5)
Amphotericin B
    0.5 mg/kg2.7 (2.2-3.2)3.4 (2.3-4.7)3.0 (2.5-3.4)3.4 (3-3.9)3.1 (2.7-3.5)3.3 (2.8-3.8)
    1.0 mg/kg2.2 (1.8-2.6)2.3* (1.7-2.9)2.2 (1.9-2.3)2.3* (1.6-3.0)3.0 (2.5-3.6)4.3 (3.7-4.8)
Fluconazole
    400 mg3.3 (2.7-3.9)3.4 (2.8-3.9)3.0 (2.4-3.6)4.3 (3.9-4.7)3.3 (2.9-3.7)3.3 (2.8-3.8)
    800 mg3.4 (2.6-4.2)3.3 (2.8-4.1)3.0 (2.6-3.4)3.7 (3.2-4.2)3.4 (2.9-3.9)3.7 (3.1-4.3)
Voriconazole
    4.0 mg/kg2.3 (1.7-2.8)2.3* (1.8-2.8)3.0 (2.6-3.4)3.2 (2.7-3.7)3.1 (2.6-3.8)3.1 (2.8-3.4)
  • a *, significantly different from control at 48 h (P = 0.037). All other values not significant.