TABLE 2

Univariate and multivariate analysis of variables associated with 30-day mortality rate in patients with bacteremia due to colistin-resistant Klebsiella pneumoniae with high-level meropenem resistancea

VariableNo. (%) of patientsUnivariate analysisMultivariate analysis with propensity score as covariableMultivariate analysis using the inverse probability weighted-cohort
Survivors (n = 72)Nonsurvivors (n = 32)HR (95% CI)PHR (95% CI)PHR (95% CI)P
Age (yr), median (IQR)65.0 (51–73.2)63.5 (47–72.25)0.99 (0.98–1.02)0.87
Male sex39 (54.2)18 (56.2)1.16 (0.58–2.3)0.68
Diabetes mellitus23 (31.9)13 (40.6)1.32 (0.65–2.67)0.45
Charlson score, Median (IQR)4 (2–6)4 (2–6)1.00 (0.9–1.11)0.9
Pitt score, Median (IQR)3 (2–5)4 (2–6)1.1 (0.95–1.28)0.22
Septic shock31 (43.1)17 (53.1)1.59 (0.79–3.2)0.196.03 (1.65–21.9)0.0066.53 (3.00–14.24)<0.001
Source of bacteremia
    Primary bacteremia29 (40.3)9 (28.1)ReferenceReferenceReferenceReference
    Urinary tract infection19 (26.4)8 (25)1.16 (0.45–3)0.761.9 (0.71–5.33)0.22.97 (1.42–6.24)0.004
    Pneumonia24 (33.3)15 (46.9)1.45 (0.64–3.3)0.372.5 (0.9–6.97)0.084.75 (2.34–9.67)<0.001
Ward of admission when the bacteremia was diagnosed
    Medical24 (33.3)5 (15.6)ReferenceReferenceReferenceReference
    Surgical13 (18.1)6 (18.8)1.86 (0.57–6.11)0.32.04 (0.5–8.9)0.342.10 (0.74–5.97)0.17
    Critical care35 (48.6)21 (65.6)2.61 (0.98–6.92)0.052.87 (0.99–8.27)0.054.22 (1.97–9.03)<0.001
Mechanical ventilation34 (47.9)16 (50)1.1 (0.54–2.18)0.81
Appropriate empirical therapy41 (57.7)14 (43.8)0.6 (0.28–1.12)0.10.53 (0.26–1.1)0.090.48 (0.26–0.88)0.02
Targeted treatment
    Monotherapy18 (25)14 (43.8)ReferenceReferenceReferenceReferenceReference
    Combination therapy54 (75)18 (56.2)0.52 (0.26–1.05)0.070.81 (0.27–2.42)0.710.62 (0.27–1.41)0.25
    Interaction of septic shock and combination therapy0.14 (0.03–0.65)0.010.10 (0.03–0.32)<0.001
Propensity score1.1 (0.26–4.56)0.630.54 (0.04–6.59)0.93
  • a Abbreviations: IQR, interquartile range; HR, hazard ratio; CI, confidence interval.