TABLE 1.

MICs of PAO1, B1, and the sensitive mutants characterized

StrainMIC (μg/ml)a
AMK (n)bAMK + CP (n)AMK + VP (n)POLYB (n)GEN (n)KAN (n)STR (n)TOB (n)
PAO14 (25)4 (8)4 (8)2 (8)4 (4)200 (4)64 (4)4 (4)
B125 (21)25 (8)25 (8)2 (8)200 (4)800 (4)>4,000 (4)200 (4)
M58 (13)8 (8)8 (8)2 (8)200 (4)800 (4)>4,000 (4)200 (4)
M314 (25)4 (8)4 (8)2 (8)64 (4)400 (4)2,000 (4)64 (4)
M5010 (6)10 (8)10 (8)2 (8)
M528 (6)8 (8)8 (8)2 (8)
  • a AMK, amikacin; CP, carbonyl cyanide m-chlorophenylhydrazone (250 μM); VP, verapamil (100 μg/ml); POLYB, polymyxin B; GEN, gentamicin; KAN, kanamycin; STR, streptomycin; TOB, tobramycin.

  • b n, number of replicates.