TABLE 3.

Susceptibility testing results by CLSI method for Cryptococcus neoformans isolates from patients with subsequent success or failure of antifungal treatment after 2 weeks of antifungal therapy (74 strains)

Treatment and outcomeaNo. of strainsGeometric mean MIC (μg/ml)b
AMBFCZ5FC
AMB alone
    Success110.22
    Failure110.39
FCZ alone
    Success110.56
    Failure40.21
AMB + 5FC
    Success190.272.24
    Failure180.222.87
  • a Treatment success was defined as the absence of clinical signs of infection (fever, meningitis, neurological disorders, and abnormal mental status), and failure was defined by death or persistence of clinical signs at Wk2.

  • b AMB, amphotericin B; FCZ, fluconazole; 5FC, flucytosine.