TABLE 1.

Demographic, clinical, and therapeutic data for 74 patients with a first episode of culture-confirmed cryptococcosis

CharacteristicNo. (%) of patients in the different treatment groupsc
AMB alone (n = 22)FCZ alone (n = 15)AMB + 5FC (n = 37)All (n = 74)
Sex
    Male21 (95)12 (80)31 (84)64 (86)
    Female1 (5)3 (20)6 (16)10 (14)
HIV infected20 (91)10 (67)30 (81)60 (81)
Fungal infectiona
    Meningitis21 (95)12 (80)36 (97)69 (93)
    Dissemination15 (68)11 (73)27 (73)53 (72)
Treatment outcomeb
    Success11 (50)11 (73)19 (51)41 (55)
    Failure11 (50)4 (27)18 (49)33 (45)
  • a Meningitis was defined as positive CSF, as detected by a positive culture of C. neoformans, positive India ink examination, and/or positive antigen detection. Dissemination was defined as the isolation of C. neoformans from two or more noncontiguous sites.

  • b Treatment success was defined as the absence of clinical signs of infection (fever, meningitis, neurological disorders, and abnormal mental status) and failure by death or persistence of clinical signs at Wk2.

  • c AMB, amphotericin B; FCZ, fluconazole; 5FC, flucytosine.