TABLE 2.

Effect of POS and CSP combinations on mouse survival against Aspergillus strains

StrainCombination% Survival with POS alonea,c% Survival with CSP alonea,c
Dose levels (POS + CSP) (mg/kg)b% SurvivalcP valuedDldEndDldEnd
DldEnd
A. fumigatus ND15825 + 101001001.0094942525
25 + 51001001.0094941919
25 + 11001001.00949477
5 + 1069690.5363632525
5 + 550440.5163631919
5 + 163570.92636377
1 + 1032320.97772525
1 + 519190.64771919
1 + 1000.897777
A. fumigatus ND2315 + 592920.9992925050
5 + 188880.6692925454
5 + 0.292920.979292134
1 + 579790.0450385050
1 + 175750.1350385454
1 + 0.279630.055038134
0.2 + 571710.16825050
0.2 + 179790.08825454
0.2 + 0.238340.0482134
A. flavus ND835 + 1100820.12100198857
5 + 0.2100250.4910019887
5 + 0.05100190.9410019820
0.5 + 1100380.7410008857
0.5 + 0.2940<0.00011000887
0.5 + 0.0510000.00721000820
0.1 + 1100690.4110008857
0.1 + 0.21000<0.00011000887
0.1 + 0.058200.141000820
  • a POS or CSP alone at the dose levels used in the combination.

  • b Treatment occurred once daily starting at 4 h postinfection through day 7 for A. fumigatus ND158 and ND231 and day 3 for A. flavus ND83.

  • c Survival of mice on the day after the last dose (dld; day 8 for ND158 and ND231 and day 4 for ND83) or the end of the experiment (day 14 for ND158 and day 15 for ND231 and ND83). Data are averages of two experiments for ND158 and ND83 and of three experiments for ND231 (eight mice per group per experiment).

  • d P values from log-rank or Fisher's exact tests comparing survival curves (from day 0 to end of experiment) of combinations versus the most active monotherapy at the dose level used in the combination. A significant difference between survival curves was observed if the P value is <0.05.