TABLE 2

Final model PK parameter estimates for EMB in New Zealand White rabbitsa

ParameterbEstimateError (CV%)c
Cl (liters/h)32.423.0
Vc (liters)5.715.60
kcp (h−1)0.50016.6
kpc (h−1)0.21015.6
kcl (h−1)8.109.72
kccell (h−1)7.5225.0
kccas (h−1)2.4417.6
Rcl3.9024.4
Rccell3.3319.9
Rccas2.4150.2
  • a Rabbits received a daily dose of 100 mg/kg.

  • b Cl, drug clearance; Vc, central compartment volume; kcp, kpc, kcl, kccell, and kccas, intercompartment rate constants where c is central compartment, l is lung, cell is cellular lesion, and cas is caseous or necrotic lesion; Rcl, Rccell, and Rccas, compartmental penetration coefficients.

  • c CV%, percent coefficient of variation.