TABLE 3.

Population pharmacokinetic model with covariates for mefloquinea

ParameterbEstimated value (SE)90% Prediction interval
Group
    CL/F (liters/kg/day)0.722 (0.034)0.463-1.126
    Effect of weight on CL/F−0.011 (0.003)
    V/F (liters kg−1)10.966 (0.863)4.987-24.113
    Effect of temp on V/F−1.739 (0.594)
    ke (day−1)0.066
    Elimination t1/2 (day)10.5
    AUC0→ (ng/ml · day)33,241
    σ2CL (CV) (%)27
    σ2V (CV) (%)48
    σ2ε (ng/ml)179
Each patientc
    AUC0→ (ng/ml · day)31,39520,523-49,239
    Cmax (ng/ml)2,202915-3,730
    Tmax (day)2.42.3-2.6
  • a Data represent results for 50 patients and 201 concentrations (AIC = 2,892).

  • b All parameter estimates are for the average person (admission temperature, 37°C; weight, 45 kg). CL/F, apparent clearance; V/F, apparent volume of distribution; ke, elimination rate constant; t1/2, elimination half-life; AUC0→, area under the whole-blood concentration-time curve; σ2CL, unexplained between-subject variance around the population average CL/F; σ2V, unexplained between-subject variance around the population average V/F; σ2ε, variance of the residual error.

  • c Values in columns 2 and 3 were calculated using the actual dose given and the actual time of dosing and represent median and 90% range values, respectively.