Parameter^{b} | Estimated value (SE) | 90% Prediction interval |
---|---|---|

Group | ||

CL/F (liters/kg/day) | 0.722 (0.034) | 0.463-1.126 |

Effect of weight on CL/F | −0.011 (0.003) | |

V/F (liters kg^{−1}) | 10.966 (0.863) | 4.987-24.113 |

Effect of temp on V/F | −1.739 (0.594) | |

k (day_{e}^{−1}) | 0.066 | |

Elimination t_{1/2} (day) | 10.5 | |

AUC_{0→}_{∞} (ng/ml · day) | 33,241 | |

σ^{2}_{CL} (CV) (%) | 27 | |

σ^{2} (CV) (%)_{V} | 48 | |

σ^{2}_{ε} (ng/ml) | 179 | |

Each patient^{c} | ||

AUC_{0→}_{∞} (ng/ml · day) | 31,395 | 20,523-49,239 |

C_{max} (ng/ml) | 2,202 | 915-3,730 |

T_{max} (day) | 2.4 | 2.3-2.6 |

↵

*a*Data represent results for 50 patients and 201 concentrations (AIC = 2,892).↵

*b*All parameter estimates are for the average person (admission temperature, 37°C; weight, 45 kg). CL/*F*, apparent clearance;*V*/*F*, apparent volume of distribution;*k*, elimination rate constant;_{e}*t*_{1/2}, elimination half-life; AUC_{0→}_{∞}, area under the whole-blood concentration-time curve; σ^{2}_{CL}, unexplained between-subject variance around the population average CL/F; σ^{2}, unexplained between-subject variance around the population average_{V}*V*/*F*; σ^{2}_{ε}, variance of the residual error.↵

*c*Values in columns 2 and 3 were calculated using the actual dose given and the actual time of dosing and represent median and 90% range values, respectively.