TABLE 2.

Population pharmacokinetic parameters for the base model of mefloquine

ParameterbMefloquinea administered with artesunate in three doses (8 mg/kg/day)
Estimated value (SE)90% Prediction interval
CL/F (liters kg−1day−1)0.755 (0.041)0.436-1.306
V/F (liters kg−1)10.172 (0.777)4.395-23.541
ke (day−1)0.074
Elimination t1/2 (days)9.4
AUC0→ (ng/ml · day)31,788
σCL (CV) (%)33
σV (CV) (%)51
σε (ng/ml)179
  • a Data represent results for 50 patients and 201 concentrations (AIC = 2,908).

  • b CL/F, apparent clearance; V/F, apparent volume of distribution; ke, elimination rate constant; t1/2, elimination half-life; AUC0→, area under the whole-blood concentration-time curve; σ2CL, unexplained between-subject variance around the population average CL/F; σ2V, unexplained between-subject variance around the population average V/F; σ2ε, variance of the residual error.