TABLE 2

In vitro activity of cefiderocol and comparators against Gram-negative bacilli (n = 4,966) isolated by 49 medical center laboratories in Europe from 2014 to 2015

Family/genus/species (no. of isolates)Antimicrobial agentMIC (μg/ml)aMIC interpretationb
RangeMIC50MIC90% susceptible% intermediate% resistant
Enterobacteriaceae (3,080)Cefiderocol≤0.002–80.121
Cefepime≤0.06 to >64≤0.06>6481.63.115.4
Ceftazidime-avibactam≤0.06 to >640.120.598.601.4
Ceftolozane-tazobactam≤0.06 to >640.25887.12.410.5
Ciprofloxacin≤0.12 to >8≤0.12>880.51.817.8
Colistin≤0.25 to >80.5>882.0018.0
Meropenem≤0.06 to >64≤0.060.1295.00.54.1
Meropenem-nonsusceptible Enterobacteriaceae (139)Cefiderocol0.008–814
Cefepime0.25 to >64>64>646.51.492.1
Ceftazidime-avibactam≤0.06 to >641>6471.9028.1
Ceftolozane-tazobactam0.5 to >64>64>645.02.292.8
Ciprofloxacin≤0.12 to >8>8>810.81.487.8
Colistin≤0.25 to >81>872.7027.3
Meropenem2 to >6416>64010.189.9
Klebsiella spp.c (1,021)Cefiderocol≤0.002–80.122
Cefepime≤0.06 to >64≤0.06>6470.33.326.4
Ceftazidime-avibactam≤0.06 to >640.12197.802.3
Ceftolozane-tazobactam≤0.06 to >640.256483.01.315.8
Ciprofloxacin≤0.12 to >8≤0.12>872.32.625.1
Colistin≤0.25 to >80.5195.005.0
Meropenem≤0.06 to >64≤0.06289.91.09.1
Klebsiella pneumoniae (761)Cefiderocol≤0.002–80.122
Cefepime≤0.06 to >640.12>6463.13.033.9
Ceftazidime-avibactam≤0.06 to >640.25197.102.9
Ceftolozane-tazobactam≤0.06 to >640.56478.21.320.5
Ciprofloxacin≤0.12 to >8≤0.12>864.42.832.9
Colistin≤0.25 to >80.5193.306.7
Meropenem≤0.06 to >64≤0.06886.71.312.0
Klebsiella oxytoca (260)Cefiderocol≤0.002–20.030.25
Cefepime≤0.06 to >64≤0.06191.54.24.2
Ceftazidime-avibactam≤0.06 to >640.120.2599.600.4
Ceftolozane-tazobactam≤0.06 to >640.250.596.91.21.9
Ciprofloxacin≤0.12 to >8≤0.12≤0.1295.42.32.3
Colistin≤0.25–20.5110000
Meropenem≤0.06–8≤0.06≤0.0699.200.8
Escherichia coli (789)Cefiderocol≤0.002–40.120.5
Cefepime≤0.06 to >64≤0.066481.63.614.8
Ceftazidime-avibactam≤0.06–320.120.2599.800.3
Ceftolozane-tazobactam≤0.06 to >640.250.596.50.43.2
Ciprofloxacin≤0.12 to >8≤0.12>872.90.526.6
Colistin≤0.25 to >80.5199.500.5
Meropenem≤0.06–4≤0.06≤0.0699.600.4
Serratia spp.d (493)Cefiderocol≤0.002–80.120.5
Cefepime≤0.06 to >640.120.594.11.04.9
Ceftazidime-avibactam≤0.06 to >640.120.599.200.8
Ceftolozane-tazobactam0.12 to >640.5195.31.82.8
Ciprofloxacin≤0.12 to >8≤0.12193.72.24.1
Colistin0.5 to >8>8>85.1094.9
Meropenem≤0.06–64≤0.060.1299.001.0
Serratia marcescens (455)Cefiderocol≤0.002–80.120.5
Cefepime≤0.06 to >640.120.593.61.15.3
Ceftazidime-avibactam≤0.06 to >640.120.599.100.9
Ceftolozane-tazobactam0.25 to >640.5195.22.02.9
Ciprofloxacin≤0.12 to >8≤0.12193.42.44.2
Colistin0.5 to >8>8>85.5094.5
Meropenem≤0.06–64≤0.060.1298.901.1
Serratia liquefaciens (33)Cefiderocol0.015–0.250.060.12
Cefepime≤0.06–0.25≤0.060.1210000
Ceftazidime-avibactam0.12–10.250.510000
Ceftolozane-tazobactam0.25–10.5110000
Ciprofloxacin≤0.12–0.5≤0.12≤0.1210000
Colistin>8>8>800100
Meropenem≤0.06–0.25≤0.060.1210000
Enterobacter spp.e (530)Cefiderocol0.008–80.251
Cefepime≤0.06 to >64≤0.061685.74.210.2
Ceftazidime-avibactam≤0.06 to >640.250.597.902.1
Ceftolozane-tazobactam≤0.06–640.5875.77.616.8
Ciprofloxacin≤0.12 to >8≤0.12190.02.17.9
Colistin≤0.25 to >80.5194.305.7
Meropenem≤0.06–64≤0.060.1296.20.63.2
Enterobacter cloacae (301)Cefiderocol0.008–40.251
Cefepime≤0.06 to >640.123278.46.615.0
Ceftazidime-avibactam≤0.06 to >640.25196.403.7
Ceftolozane-tazobactam≤0.06 to >640.51674.13.022.9
Ciprofloxacin≤0.12 to >8≤0.12885.12.712.3
Colistin≤0.25 to >80.5195.704.3
Meropenem≤0.06–64≤0.060.2593.71.05.3
Enterobacter aerogenes (204)Cefiderocol0.015–80.120.5
Cefepime≤0.06 to >64≤0.06194.61.04.4
Ceftazidime-avibactam≤0.06–80.250.510000
Ceftolozane-tazobactam0.12–320.5477.014.28.8
Ciprofloxacin≤0.12 to >8≤0.120.2596.11.52.5
Colistin≤0.25 to >80.5198.501.5
Meropenem≤0.06–64≤0.060.1299.500.5
Citrobacter spp.f (247)Cefiderocol0.004–40.120.5
Cefepime≤0.06 to >64≤0.06194.32.03.6
Ceftazidime-avibactam≤0.06 to >640.120.598.401.6
Ceftolozane-tazobactam0.12 to >640.25882.63.214.2
Ciprofloxacin≤0.12 to >8≤0.12191.50.48.1
Colistin≤0.25 to >80.5199.600.4
Meropenem≤0.06–8≤0.06≤0.0696.80.42.8
Citrobacter freundii (160)Cefiderocol0.004–20.120.5
Cefepime≤0.06 to >64≤0.06292.52.55.0
Ceftazidime-avibactam≤0.06 to >640.120.598.101.9
Ceftolozane-tazobactam0.12 to >640.251675.63.820.6
Ciprofloxacin≤0.12 to >8≤0.12488.1011.9
Colistin≤0.25–20.5110000
Meropenem≤0.06–8≤0.060.1295.60.63.8
Citrobacter koseri (73)Cefiderocol0.008–40.250.5
Cefepime≤0.06–8≤0.06≤0.0698.61.40
Ceftazidime-avibactam≤0.06–10.120.2510000
Ceftolozane-tazobactam0.12–40.250.598.61.40
Ciprofloxacin≤0.12 to >8≤0.12≤0.1298.601.4
Colistin≤0.25 to >80.5198.601.4
Meropenem≤0.06–0.12≤0.06≤0.0610000
Pseudomonas aeruginosa (765)Cefiderocol≤0.002–40.120.5
Cefepime≤0.06 to >6443282.17.510.5
Ceftazidime-avibactam≤0.06 to >642891.608.4
Ceftolozane-tazobactam≤0.06 to >640.5490.92.17.1
Ciprofloxacin≤0.12 to >80.25>874.04.122.0
Colistin≤0.25 to >81298.70.50.8
Meropenem≤0.06 to >640.51673.65.221.2
Meropenem-nonsusceptible Pseudomonas aeruginosa (202)Cefiderocol0.008–40.251
Cefepime1 to >6416>6447.518.334.2
Ceftazidime-avibactam1 to >6486468.3031.7
Ceftolozane-tazobactam0.5 to >641>6467.35.926.7
Ciprofloxacin≤0.12 to >88>834.75.060.4
Colistin≤0.25–41199.01.00
Meropenem4 to >64816019.880.2
Acinetobacter baumannii (839)Cefiderocol0.004–640.121
Cefepime≤0.06 to >6464>6426.512.561.0
Ceftazidime-avibactam≤0.06 to >6416>64
Ceftolozane-tazobactam≤0.06 to >64864
Ciprofloxacin≤0.12 to >8>8>821.90.178.0
Colistin≤0.25 to >81>887.5012.5
Meropenem≤0.06 to >6432>6429.10.670.3
Meropenem-nonsusceptible Acinetobacter baumannii (595)Cefiderocol0.004–640.121
Cefepime4 to >6464>642.413.684.0
Ceftazidime-avibactam1 to >6432>64
Ceftolozane-tazobactam1 to >6416>64
Ciprofloxacin≤0.12 to >8>8>80.2099.8
Colistin≤0.25 to >81>882.7017.3
Meropenem4 to >6464>6400.899.2
Stenotrophomonas maltophilia (276)Cefiderocol0.004–20.060.25
Cefepime0.5 to >6432>64
Ceftazidime-avibactam0.5 to >641664
Ceftolozane-tazobactam0.12 to >648>64
Ciprofloxacin≤0.12 to >828
Colistin≤0.25 to >81>8
Meropenem0.12 to >64>64>64
Burkholderia cepacia (6)Cefiderocol0.004–1
Cefepime16 to >64
Ceftazidime-avibactam2–32
Ceftolozane-tazobactam1–64
Ciprofloxacin0.5 to >8
Colistin≤0.25 to >8
Meropenem2–1666.7033.3
  • a MIC50 and MIC90 calculated only for genus or species where >30 isolates were tested. Species of Enterobacteriaceae with <30 isolates were grouped with the overall genus data.

  • b Blank spaces mean that there are no CLSI, EUCAST, or FDA MIC breakpoints available for this agent.

  • c The 1,021 isolates of Klebsiella spp. were composed of 761 Klebsiella pneumoniae and 260 Klebsiella oxytoca isolates.

  • d The 493 isolates of Serratia spp. were composed of 455 Serratia marcescens, 33 Serratia liquefaciens, 3 Serratia ureilytica, 1 Serratia odorifera, and 1 Serratia rubidaea isolates.

  • e The 530 isolates of Enterobacter spp. were composed of 301 Enterobacter cloacae, 204 Enterobacter aerogenes, 19 Enterobacter asburiae, 4 Enterobacter kobei, and 2 Enterobacter ludwigii isolates.

  • f The 247 isolates of Citrobacter spp. were composed of 160 Citrobacter freundii, 73 Citrobacter koseri, 9 Citrobacter braakii, 3 Citrobacter amalonaticus, and 2 Citrobacter farmeri isolates.