TABLE 3

PK parameters of EMB in 1,000 simulated adult female New Zealand White rabbits receiving 200 mg/kg daily

CompartmentCmax (mg/liter)AUC0–24 (mg · h/ml)T1/2 (h)b
EstimateError (CV%)aEstimateError (CV%)EstimateError (CV%)
Plasma5.3218.224.25.204.406.9
Lung22.025.128218.16.5412.0
Cellular lesion18.428.126112.28.9218.5
Caseous lesion17.114.821218.815.742.0
  • a CV%, percent coefficient of variation.

  • b T1/2, half-life.