TABLE 4.

Drug binding affinity to double-stranded DNA hairpin oligonucleotides

DrugApparent Kd (μM)
5′-TGGCCTCC 3′-ACCGGACC5′-TAACCTCC 3′-ATTGGACC
PD0117962329.5 ± 38.7369.3 ± 55.0
PD0129603342.3 ± 47.2336.4 ± 40.3
PD0163449427.9 ± 73.1438.3 ± 61.6
Ciprofloxacin320.2 ± 64.6348.0 ± 68.0
PD0164488287.0 ± 43.0362.3 ± 58.0
Difloxacin346.4 ± 34.2534.6 ± 58.6
Ofloxacin362.0 ± 49.1465.4 ± 30.2
Enoxacin264.0 ± 38.3335.6 ± 51.0
Norfloxacin309.0 ± 53.6333.9 ± 45.9
Pefloxacin291.8 ± 30.1322.9 ± 67.6
Oxolinic acid504.4 ± 145.3335.9 ± 68.4
Piromidic acid497.3 ± 106.3681.1 ± 183.2