TABLE 3.

Induction of efflux genes by tigecycline and tetracyclinea

TreatmentFold change
mexZmexXmexYoprM
TGC, 1 μg/ml4.5213.4312.850.9
TGC, 2 μg/ml5.2815.4813.340.63
TGC, 4 μg/ml10.9214.8511.450.47
TET, 4 μg/ml4.9315.81140.78
  • a Values represent fold changes in transcript levels detected compared to untreated control samples and are averages of two biological replicates. TGC, tigecycline; TET, tetracycline.