TABLE 3.

Complementation of an OprM mutant with OpmG and OpmH

StrainPhenotype of strain and plasmidMIC (μg/ml)a
KmGmEryClinFusCmTcCbImiMerCtzNalNfxPmbAcrCV
H730Parent503.1125>7505007.8512.5>50.630.032631.00.316363
H743OprM251.67.823161.00.630.7850.630.02161.00.317.863
H743(pJJ106)OprM + OpmG250.8>500>75025016>200.7850.630.04250640.313131
H743(pJJ105)OprM + OpmH500.8>500>75025031100.7850.630.04250640.166363
  • a Abbreviations: Km, kanamycin; Gm, gentamicin; Ery, erythromycin; Clin, clindamycin; Fus, fusidic acid; Cm, chloramphenicol; Tc, tetracycline; Cb, carbenicillin; Imi, imipenem; Mer, meropenem; Ctz, ceftazidime; Nal, nalidixic acid; Nfx, norfloxacin; Pmb, polymyxin B; Acr, acriflavin; CV, crystal violet.