TABLE 4.

Effects of glycylcycline substitutions on efflux

StrainDeletion(s)MIC (μg/ml)a
MINDOXTETTGCDMG-MINODMG-DMDOTPAM-MINO
K767None (wild type)1616168884
K1525 mexXY 4440.50.50.50.5
XY11281283248168
XY36464644884
K1542 mexB/mexXY 0.50.250.50.50.250.1250.25
BXY112812864816168
BXY41286432416168
K1119 mexAB-oprM 0.50.250.250.50.250.1250.25
M112812864816168
M912812864816168
  • a Abbreviations: DOX, doxycycline; MIN, minocycline; TET, tetracycline, TGC, tigecycline. See Fig. 4 for structures of DMG-MINO, DMG-DMDOT, and PAM-MINO.