TABLE 1.

In vitro susceptibilities of 3,959 clinical isolates of Candida spp. to caspofungin, fluconazole, and itraconazolea

Organism (no. tested) and antifungal agentMIC (μg/ml)b% Susceptible at MIC (μg/ml) of:
Range50%90%0.120.250.51248
C. albicans (2,453)
    Caspofungin0.007->80.120.2579979999999999
    Fluconazole0.12->1280.250.524829194959697c
    Itraconazole0.007->80.030.1293d969899999999
C. glabrata (512)
    Caspofungin0.007->80.120.2558919999999999
    Fluconazole0.12->1288320.20.612123360c
    Itraconazole0.007->8124d184680919496
C. parapsilosis (420)
    Caspofungin0.03->814262560879599
    Fluconazole0.12-640.521115178939799c
    Itraconazole0.015-20.120.2554d909999100
C. tropicalis (285)
    Caspofungin0.03->80.120.560869698989898
    Fluconazole0.12->1280.522205582959798c
    Itraconazole0.015->80.120.558d869699999999
C. dubliniensis (88)
    Caspofungin0.015-10.250.5358398100
    Fluconazole0.12->1280.251645818485858589c
    Itraconazole0.015->80.060.2584d949898989898
C. guilliermondii (75)
    Caspofungin0.12->8>8>8135571113
    Fluconazole0.25->1284160126216481c
    Itraconazole0.03->8117d244897979999
C. krusei (72)
    Caspofungin0.12-2111104399100
    Fluconazole4-12832640000015c
    Itraconazole0.12-20.512d185795100
C. lusitaniae (26)
    Caspofungin0.12-20.5111238196100
    Fluconazole0.12-160.522386486979798c
    Itraconazole0.03-20.120.2550d919898100
C. famata (9)
    Caspofungin0.06->8411112233445656
    Fluconazole0.25-1620133347537389c
    Itraconazole0.06-10.2533d6080100
Candida spp.e (19)
    Caspofungin0.03-80.51253175949494100
    Fluconazole0.12-128464471125397586c
    Itraconazole0.015->80.25129d688696969696
  • a BMD testing according to NCCLS M27-A2 (17).

  • b 50% and 90%, MICs encompassing 50 and 90% of isolates tested, respectively.

  • c Percentage of isolates susceptible to fluconazole at the NCCLS breakpoint of ≤8 μg/ml.

  • d Percentage of isolates susceptible to itraconazole at the NCCLS breakpoint of ≤0.12 μg/ml.

  • e Includes C. kefyr (four isolates), C. rugosa (six isolates), C. pelliculosa (three isolates), C. lambica (two isolates), and one isolate each of C. lipolytica, C. humicola, and C. zeylanoides.