TABLE 2.

Properties of drugs

DrugIC50 (μM)aCleavage specificityDNA unwinding (ΔLk°/mM)b
PD01179620.7I12
PD01296030.8I17
PD01634490.9I5.4
Ciprofloxacin1.1I33
PD01644881.7I4.3
Difloxacin2.5INDc
Ofloxacin3.5I9.5
Enoxacin4.4I29
Norfloxacin4.8I13
Pefloxacin5.1I11
Oxolinic acid15.1II6.0
Piromidic acid56IIND
Pipemidic acid70IIND
  • a Data for all drugs except pefloxacin, difloxacin, pipemidic acid, piromidic acid, and oxolinic acid are from Barnard and Maxwell (2).

  • b ΔLK°/mM, average change in mean linking difference per millimolar drug.

  • c ND, not determined.