TABLE 2.

Synergism between ergosterol biosynthesis inhibitors and calcineurin inhibitors is FKBP12 and calcineurin dependent

Genotype (C. albicans strain)MIC100 alone (μg/ml)aMIC100 combineda,bFIC indexa
CsAFK506FTCsA/FCsA/TFK506/FFK506/TCsA/FCsA/TFK506/FFK506/T
Wild type (SC5314)>3.12>3.123.12>10.51.56/0.040.78/3.12≤0.04/≤0.010.09/0.390.260.240.0040.03
cnb1/cnb1 (DAY364)>3.12>3.12≤0.010.39≤0.04/≤0.01≤0.04/0.39≤0.04/≤0.01≤0.04/0.391.0031.0031.0031.003
cnb1/cnb1 CNB1 (MCC85)>3.12>3.120.78>12.50.78/0.040.19/3.12≤0.04/≤0.01≤0.04/0.780.170.150.0090.03
CNB1-1/CNB1 (YAG237)>3.12>3.123.12>12.51.56/0.190.78/3.12>3.12/3.12>3.12/>12.50.310.252.02.0
rbp1/rbp1 (YAG171)>3.12>3.123.12>12.50.19/0.780.39/1.56>3.12/3.12>3.12/>12.50.280.122.02.0
  • a F, fenpropimorph; T, terbinafine.

  • b Combined MICs, expressed as [drug 1]/[drug 2] are the minimum concentrations of drugs 1 and 2 required to inhibit cell growth when the two drugs were used in combination.