TABLE 4.

Frequency and distribution of multiple mutations in individual M. tuberculosis isolates

GeneLocation of mutationNo. (%) of isolates with mutations in indicated gene location
katGinhAahpCkasAndh
AllPosition 315Positions other than 315AllPromoterORFAllPromoterORFD73HAllPosition 269Position 312
katGAll238 (100)221 (100)17 (100)5 (11)2 (5)3 (25)20 (27)14 (24)6 (43)5 (38)34 (24)29 (24)5 (26)9 (30)
Position 315221 (93)221 (100)05 (11)2 (5)3 (25)15 (21)9 (15)6 (43)5 (38)34 (24)29 (24)5 (26)9 (30)
Positions other than 31517 (7)017 (100)0005 (7)5 (8)000000
inhAAll5 (2)5 (2)046 (100)39 (100)12 (100)6 (8)6 (10)005 (3)3 (2)2 (11)1 (3)
Promoter2 (1)2 (1)039 (85)39 (100)5 (42)6 (8)6 (10)003 (2)1 (1)2 (11)0
ORF3 (1)3 (1)012 (26)5 (13)12 (100)1 (1)1 (2)003 (2)2 (2)1 (5)1 (3)
ahpCAll20 (8)15 (7)5 (29)6 (13)6 (15)1 (8)73 (100)59 (100)14 (100)13 (100)0002 (7)
Promoter14 (6)9 (4)5 (29)6 (13)6 (15)059 (81)59 (100)000001 (3)
ORF6 (3)6 (3)0001 (8)14 (19)014 (100)13 (100)0001 (3)
D73H5 (2)5 (2)000013 (18)013 (93)13 (100)0000
kasAAll34 (14)34 (15)05 (11)3 (8)3 (25)0000144 (100)123 (100)19 (100)0
Position 26929 (12)29 (13)03 (7)1 (3)2 (17)0000123 (85)123 (100)00
Position 3125 (2)5 (2)02 (4)2 (5)1 (8)000019 (13)019 (100)0
ndhAll9 (4)9 (4)01 (2)01 (8)2 (3)1 (2)1 (7)000030 (100)