TABLE 1.

MIC and FICI results for the Aspergillus spp. at 24 h

Aspergillus sp. (n) and strainEnd pointConcna (μg/ml) ofd:FICIResultb
CAS (alone)ITZ (alone)CAS (alone)ITZ (alone)
A. fumigatus (13)
    AF293MIC12810.25S
    MEC0.0080.252.01
    AF1MIC1280.50.37S
    MEC0.0150.251.121
    AF2MIC1280.50.25S
    MEC0.0150.251.5I
    AF3MIC1280.50.25S
    MEC0.0150.252.25I
    AF4MIC12810.25S
    MEC0.060.253.0I
    AF5MIC1280.50.25S
    MEC0.0150.252I
    AF6MIC1280.50.25S
    MEC0.030.251.5I
    AF7MIC12810.25S
    MEC0.0150.251.12I
    AF8MIC1280.50.25S
    MEC0.0150.252.25I
    AF9MIC1280.50.25S
    MEC0.0080.251.12I
    AF10MIC1280.50.37S
    MEC0.0080.251.12I
    AF11MIC640.50.25S
    MEC0.0080.1251.25I
    AF12MIC1280.50.25S
    MEC0.030.252.12I
A. niger (6)
    ANeMIC1610.75Ad
    MEC0.030.1251.25I
    AN1MIC160.51.25I
    MEC0.0150.251.12I
    AN2MIC1610.75Ad
    MEC0.0150.251.12I
    AN2MIC1610.75Ad
    MEC0.0150.251.12I
    AN3MIC3210.31S
    MEC0.0150.251.12I
    AN4MIC320.50.75Ad
    MEC0.030.1251.25I
    AN5MIC1610.75Ad
    MEC0.030.50.56Ad
A. flavus (6)
    Afl1MIC>128c0.50.25S
    MEC0.0150.252.12I
    Afl2MIC>1280.50.25S
    MEC0.0080.1254.0I
    Afl3MIC>1280.250.25S
    MEC0.030.062.5I
    Afl4MIC>1280.250.25S
    MEC0.030.063.0I
    Afl5MIC>1280.250.25S
    MEC0.0080.062.5I
    Afl6MIC1280.50.25S
    MEC0.0150.1253.0I
A. terreus (6)
    AT1MIC1280.50.25S
    MEC0.0150.031.5I
    AT2MIC1280.250.25S
    MEC0.030.061.0Ad
    AT3MIC1280.50.25S
    MEC0.1250.50.5Ad
    AT4MIC1280.50.25S
    MEC0.060.061.0Ad
    AT5MIC1280.50.25S
    MEC0.060.061.5I
    AT6MIC1280.50.25S
    MEC0.030.1250.75Ad
  • a MIC at 24 h or MEC at 24 h observed by microscopy.

  • b S, synergistic; Ad, additive; I, indifferent.

  • c The off-scale MIC of >128 μg/ml was converted to the next highest concentration, 256 μg/ml, for FICI calculation.

  • d CAS, caspofungin; ITZ, itraconazole.

  • e American Type Culture Collection.