TABLE 3.

Differentially expressed genes which exhibit coordinate regulation with CDR1 and CDR2 in isolates 2-79 through 12-99 in stepwise acquisition of azole resistance

GeneDescriptionFold change
2-80 vs 2-798-46 vs 2-7912-99 vs 2-7912-99 vs 8-46
CDR1 a , c Multidrug resistance protein10.99.211
CDR2 a , b , c Multidrug resistance protein0.90.98.49.4
ERG2 a C-8 sterol isomerase1.11.63.72.3
GPX1 a , b Glutathione peroxidase1.41.23.22.7
IPF12319 Unknown function1.11.12.72.5
RTA3 a , c Unknown function1.11.12.62.6
CFL2 Ferric reductase1.21.11.81.7
IPF10662 Unknown function0.80.90.60.6
EBP1 NADPH dehydrogenase0.80.90.50.6
YHB1 Flavohemoglobin10.80.50.6
  • a Gene previously reported to be differentially expressed in this set of isolates.

  • b Gene previously reported to be differentially expressed in experimental azole resistance in C. albicans.

  • c Gene with homolog in S. cerevisiae identified previously as having PDRE in its promoter.