TABLE 1.

Antifungal susceptibility of 17 C. albicans strains homozygous at the mating type-like locus (MTL)

MTL genotypeStrainMIC (μg/ml)a
Flu.Ravu.Posa.Vori.Itra.Caspo.Ampho. B5-FC
aL262.000.0600.1200.0300.5000.121.02.00
12C0.25≤0.0070.015≤0.0070.0300.060.50.25
G1060.50≤0.0070.030≤0.0070.1200.061.00.25
OKP90≤0.12≤0.0070.015≤0.0070.0300.121.016.00
P600.25≤0.0070.015≤0.0070.0600.061.00.25
P370050.25≤0.0070.030≤0.0070.0600.061.01.00
P750630.25≤0.0070.015≤0.0070.0300.121.00.12
αWO-1≤0.12≤0.0070.0300.0150.0600.121.00.12
19F0.25≤0.0070.015≤0.0070.0300.121.0≥64.00
GC75≤0.12≤0.007≤0.007≤0.0070.0300.251.00.25
P870.25≤0.0070.030≤0.0070.0600.121.00.12
P370350.500.0150.015≤0.0070.0600.061.00.25
P370370.25≤0.0070.015≤0.0070.0300.251.00.25
P37039≤0.12≤0.0070.015≤0.0070.0300.061.00.25
P570720.25≤0.007≤0.007≤0.0070.0150.061.00.12
P780480.25≤0.0070.015≤0.0070.0300.061.00.25
P800010.50≤0.0070.030≤0.0070.1200.061.00.12
All isolates
    MIC50b0.25≤0.0070.015≤0.0070.0300.061.00.25
    MIC90b0.50≤0.0070.030≤0.0070.1200.121.02.00
a/α (97%)c
    MIC50b0.25≤0.0070.015≤0.0070.0300.121.00.25
    MIC90b0.500.0150.0600.0150.0600.251.01.00
  • a Flu., fluconazole; Ravu., ravuconazole; Posa., posaconazole; Vori., voriconazole; Itra., itraconazole; Caspo., caspofungin; Ampho.B, amphotericin B.

  • b The MIC50 and MIC90 values represent the concentration of each antifungal agent that inhibited 50% and 90%, respectively, of the tested isolates.

  • c Data were obtained from Pfaller et al. (22) for a collection of 486 isolates of C. albicans tested for caspofungin and from Diekema et al. (6) for a collection of 148 isolates of C. albicans tested for the remaining antifungals. The collections used as controls were assumed to be 97% a/α based on the results of Lockhart et al. (14).