TABLE 4.

INH-resistant M. tuberculosis isolates with mutations in two or more genes

IsolateMIC (μg/ml)Mutationa
furAkatGmabAinhAoxyR-ahpCsrmR homologkasARv0340iniBiniAiniCRv1592cfadE24
UT7394S315TW83G
UT188512S315TV430A
UT2090>256124; G ins9 UPS; G→A
UT22042W91RD3G
UT3174>256DEL48 UPS; G→A
UT3230NDS315T64 UPS; 2 bp ins
UT3306>256Q434STOPV163I
UT3315NDL336PG269S
UT3437NDS315T5-bp DEL at position 94
UT3740ND147 UPS; C→TP3A
HN1984>256S315N15 UPS; C→TR537H
HN19930.19A110V15 UPS; C→TG269S
HN20290.1915 UPS; C→TI194TP42L
NHN6701.5A110V15 UPS; C→T
NHN6730.25A110V15 UPS; C→T
NHN674<0.016S5PA110V8 UPS; T→AM77I12-bp DEL at position 222
NHN681ND15 UPS; C→TI21V
  • a The single-letter amino acid designations used are as follows: A, alanine; D, aspartic acid; G, glycine; H, histidine; I, isoleucine; L, leucine; M, methionine; N, asparagine; P, proline; Q, glutamine; R, arginine; S, serine; T, threonine; V, valine; and W, tryptophan. The single-letter nucleotide designations used are as follows: A, adenine; C, cytosine; G, guanine, and T, thymidine. The other abbreviations are as follows: ins, insertion of bases; UPS, nucleotide position (base pairs) upstream of the start codon; DEL, deletion of the bases; STOP, termination mutation; ND, not determined.