TABLE 5.

MICs, catalase activity, and mutations in katG for INH-resistant M. tuberculosis isolatesa

IsolatekatG mutationbCatalase (activity height of bubbles [mm])cMIC (μg/ml)
UT450S315I1332
UT473W397Y, N529D15>256
UT561S315T261
UT739S315T104
UT1885S315T2512
UT1998S315T150.75
UT2007S315T156
UT2090124; G Ins5>256
UT2204L91R52
UT2340S315T200.38
UT2419S315T204
UT2883S315T108
UT2931S315T250.5
UT3171W90STOPNo bubbles>256
UT3174DelNo bubbles>256
UT3181DelNo bubbles>256
UT3194S315T1419
UT3306Q434STOP5>256
HN1984S315N5>256
HN1993A110V100.19
NHN670A110V91.5
NHN673A110V100.25
NHN674A110V10<0.016
H37RvWT25<0.016
  • a H37Rv was used as a positive control.

  • b The single-letter amino acid designations used are as follows: A, alanine; D, aspartic acid; I, isoleucine; L, leucine; N, asparagine; P, proline; Q, glutamine; R, arginine; S, serine; T, threonine; V, valine; W, tryptophan; and Y, tyrosine. The single-letter nucleotide designation used is as follows: G, guanine. The other abbreviations are as follows: Ins, insertion of bases; Del, deletion of the gene; STOP, termination mutation; WT, wild type.

  • c No bubbles indicates a lack of catalase activity. Only isolates with data on catalase activity are shown.