TABLE 1.

Independently determined MICs for the Y and M forms of dimorphic fungi

OrganismMIC (μg/ml)a
MCFGAMBITCFLC
H. capsulatum
    IFM41612>64/0.06250.25/0.1250.0156/0.01562/4
    IFM41329>64/0.03130.25/0.06250.0078/0.03132/16
    IFM41330>64/0.03130.125/0.125≤0.0039/0.03134/16
    G217B>64/NTb0.5/NT0.0156/NT1/NT
B. dermatitidis
    ATCC 26197>64/0.00780.125/0.0156≤0.0039/0.00782/16
    ATCC 26198>64/0.01560.125/0.01560.0156/0.00784/32
    ATCC 2619932/0.03130.125/0.01560.0078/0.03131/32
    IFM40753NT/0.0156NT/0.0156NT/0.0156NT/32
    IFM4075432/0.01560.125/0.0156≤0.0039/0.03134/32
    IFM4163464/0.00780.125/0.0156≤0.0039/0.00781/32
P. brasiliensis
    IFM41620>64/160.25/0.0156≤0.0039/≤0.00390.25/0.5
    IFM41621>64/160.25/0.0078≤0.0039/≤0.00390.5/0.5
    IFM41626>64/80.0625/0.0156≤0.0039/≤0.00390.25/1
    IFM41632>64/160.125/0.0313≤0.0039/≤0.00390.125/0.25
    IFM41633>64/80.125/0.0313≤0.0039/≤0.00390.125/1
    IFM46215>64/40.25/0.0156≤0.0039/0.00780.5/1
    IFM46930>64/40.25/0.0625≤0.0039/≤0.00390.25/1
P. marneffei
    IFM4170716/NT0.25/NT0.0156/NT2/NT
    IFM4170816/0.03130.25/0.250.0313/0.06252/4
    IFM4727916/20.5/0.250.0313/0.01562/2
    IFM472808/20.25/0.1250.0156/0.00781/2
    IFM472814/20.25/0.250.0156/0.01561/4
S. schenckii
    IFM46011>64/NT0.5/NT1/NT16/NT
    IFM4660564/NT1/NT2/NT>64/NT
    IFM4692716/11/12/0.5>64/>64
    IFM47068>64/0.51/12/1>64/>64
    IFM46989NT/1NT/2NT/1NT/>64
    IFM47069NT/1NT/2NT/1NT/>64
    IFM46990NT/1NT/1NT/1NT/>64
C. immitis
    IFM4935NT/0.0156NT/0.25NT/0.0625NT/4
    IFM4945NT/0.0156NT/0.25NT/0.125NT/4
    IFM45816NT/0.0156NT/0.0625NT/0.0625NT/4
    IFM45868NT/0.0156NT/0.25NT/0.125NT/4
  • a MICs were determined as minimum drug concentrations resulting in prominent growth inhibition compared with the growth control.

  • b NT, not tested.