TABLE 4.

Comparison of MICs for genomic DNA group 3 isolates from blood cultures 1997-2000a

AntibioticMIC (μg/ml) for isolates:
Bearing intI1-blaIMP-4 and/or 5′CS-arr-2-aacA4 (n = 17)bNot bearing either intI1-blaIMP-4 or 5′CS-arr-2-aacA4 (n = 41)c
GeomeanMIC50MIC90Min MICMax MICGeomeanMIC50MIC90Min MICMax MIC
AMK18.0832640.50641.33240.0664
GEN1.44180.06640.61120.06128
NET1.45180.25320.71120.068
IPM3.69480.25160.150.130.250.031
CIP0.420.5020.03320.330.2510.02128
SUL1.08120.5040.84120.064
TET1.57240.131281.66240.13256
SMX12812812812812816.8381,0240.251,024
RIF6.80212811281.93240.2532
CAZ96.22128128162568.568320.50128
CHL1282562561625647.55642560.50512
  • a Geomean, geometric mean of MIC; MIC50 and MIC90, MICs at which 50 and 90% of isolates are inhibited, respectively; Min MIC, minimum MIC; Max MIC, maximum MIC; AMK, amikacin; GEN, gentamicin; NET, netilmicin; IPM, imipenem; CIP, ciprofloxacin; SUL, sulbactam; TET, tetracycline; SMX, sulphamethoxazole; RIF, rifampin; CAZ, ceftazidime; CHL, chloramphenicol. By the Mann-Whitney test, for isolates bearing the intI1-blaIMP-4 and/or 5′CS-arr-2-aacA4 sequences versus isolates not bearing those sequences, P < 0.001 to 0.01 for AMK, GEN, IMP, SMX, CAZ; for other agents, P > 0.05.

  • b Fifteen isolates were tested for NET, and 5 were tested for CHL.

  • c Forty-one isolates were tested for all agents except CHL, for which 21 were tested.