TABLE 2.

MICs of ceftazidime alone or in combination with AM-112 against β-lactamase-producing bacteria

OrganismGroup/classaMIC (μg/ml)
AM-112CAZbCAZ + AM-112 (1:1)cCAZ + AM-112 (2:1)b
E. coli J53 SHV-12b/A3220.250.125
E. coli J53 SHV-22be/A160.250.1250.125
E. coli J53 SHV-32be/A80.1250.030.125
E. coli J53 SHV-42be/A32>6448
E. coli J53 SHV-52be/A3216816
E. coli J53 TEM-12b/A320.250.250.5
E. coli J53 TEM-32be/A161642
E. coli J53 TEM-62be/A32>6484
E. coli J53 TEM-92be/A32>6488
E. coli J53 TEM-102be/A32>64816
P. aeruginosa 1405-con1/C>128>643232
P. aeruginosa 2297-con1/C>128>646464
P. aeruginosa ATCC 278531/C>128242
E. cloacae P991/C163244
E. cloacae Hennessey1/C32>6444
E. cloacae 84-con1/C32>6444
C. freundii C2-con1/C32640.032
S. marcescens S2-con1/C6410.030.5
M. morganii M1-con1/C64811
E. coli J53 OXA-12d/D160.250.50.25
E. coli J53 OXA-22d/D160.250.250.25
E. coli J53 OXA-3—/D320.50.50.5
E. coli J53 OXA-52d/D320.50.250.25
  • a Group, Bush-Jacoby-Medeiros classification (4); class, Ambler molecular class (1). —, no group assigned.

  • b MICs quoted for CAZ-AM-112 combinations refer to ceftazidime component.

  • c CAZ, ceftazidime.