TABLE 1.

Susceptibilities of 400 Candida spp. to fluconazole and voriconazole as determined by three methods at two incubation times

Species (no. of isolates tested)Time (h)MethodFluconazoleaVoriconazolea
Range50%90%Rangea50%90%
C. albicans (205)24MD0.125-1280.1250.250.031-160.0310.031
ET0.125-241.520.008-0.7500.0320.047
DD45-21332945-253430
48MD0.125-1280.250.50.031-320.0310.06
ET0.094->2561.530.008-640.0320.064
DD47-NZ332945-153430
C. parapsilosis (66)24MD0.125-640.2510.031-20.0310.125
ET0.38->2561.560.008-20.0320.094
DD43-NZ362645-123931
48MD0.250-1280.540.031-40.0310.25
ET0.38->2562160.008-640.0320.25
DD44-NZ362245-NZ3825
C. tropicalis (56)24MD0.125-1280.2510.031-320.0310.125
ET0.380->2561.540.016-1.50.0640.19
DD40-10332840-123025
48MD0.125-1281160.031-320.1251
ET0.750-512260.019-640.190.75
DD38-NZ282437-NZ2418
C. glabrata (39)24MD0.250-64480.031-20.1251
ET2-5128320.047-20.1250.38
DD38-NZ272035-122924
48MD0.250-1288320.031-80.52
ET4-51224640.094-30.381
DD32-NZ191232-NZ2015
C. krusei (24)24MD0.5-12816160.031-10.1250.25
ET1.5->25648960.016-1050.190.38
DD38-NZ181442-122823
48MD1-12832640.031-20.50.5
ET2-5125125120.016-120.752
DD38-NZ0042-NZ1613
Other species (10)24MD0.125-20.250.50.0310.0310.031
ET0.5-20.7510.006-0.0230.0160.016
DD45-36403844-384138
48MD0.125-40.510.031-0.1250.0310.031
ET0.5-4110.006-0.0230.0160.016
DD45-36424045-384340
  • a The values are MICs (in micrograms per milliliter) for the MD and ET methods and inhibition zone diameter (in millimeters) for the DD method. The value shown is the lowest MIC that was greater than (for the MD and ET methods) or the greatest zone diameter that was less than (for the DD method) 50 or 90% of the observed values, as indicated. NZ, no zone.