TABLE 1.

Mean pharmacokinetic parameters ± SD for colistin and colistin A and B in rats (n = 5)

DrugCL (ml/min/kg)Vss (ml/kg)MRT (min)t1/2 (min)
Colistin5.2 ± 0.4496 ± 6094.9 ± 12.374.6 ± 13.2
Colistin A5.1 ± 0.5498 ± 7098.1 ± 15.977.1 ± 12.8
Colistin B5.3 ± 0.5509 ± 6496.1 ± 17.277.4 ± 14.8