TABLE 1.

Results of pharmacokinetic analyses

Dosing regimen (mg/kg)No. of simulationsParametera
Cp-free (μg/ml)Ct-free (μg/ml)AUC24-free (μg · h/ml)
1.0040.91 ± 0.040.12 ± 0.0211 ± 2.1
1.5041.56 ± 0.020.17 ± 0.0113 ± 1.4
2.00121.82 ± 0.050.22 ± 0.0318 ± 2.8
2.5042.41 ± 0.110.29 ± 0.0322 ± 4.5
3.00122.94 ± 0.210.37 ± 0.0726 ± 2.8
3.5043.22 ± 0.190.41 ± 0.0531 ± 3.7
4.00123.61 ± 0.070.45 ± 0.0235 ± 5.0
5.00124.58 ± 0.220.60 ± 0.0741 ± 7.3
5.5025.20 ± 0.150.65 ± 0.0544 ± 8.9
6.00125.95 ± 0.190.73 ± 0.0947 ± 12.5
6.5026.22 ± 0.110.76 ± 0.1150 ± 8.1
7.0086.60 ± 0.140.85 ± 0.0756 ± 9.2
8.0087.42 ± 0.290.90 ± 0.1062 ± 16.2
9.0048.51 ± 0.131.05 ± 0.1181 ± 11.0
  • a C p-free, free peak concentration; Ct-free, free trough concentration. Values are presented as means ± standard deviations for all simulations.