TABLE 3.

Comparison of interpretive categories for fluconazole and rates of interpretive agreementa

MethodIncubation time (h)CategoryFluconazole MIC50 (μg/ml) at 48 h by MDPredictive values (%)No. (%) of discrepant resultsbNo. (%) of total agreement
SS-DDRMinorMajorVery major
DD24S337231596.0c30 (7.5)0 (0.0)15 (3.8)355 (88.8)
I184
R021083.0d
48S32951097.1c27 (6.7)4 (1.0)10 (2.5)359 (89.8)
I5110
R4171947.5d
ET24S334141197.0c32 (8.0)1 (0.3)11 (2.8)356 (89.0)
I395
R1101354.2d
48S3190997.3c43 (10.7)5 (1.3)9 (2.3)343 (85.8)
I1451
R5281936.5d
  • a S, susceptible; I, intermediate; R, resistant; S-DD, susceptible-dose dependent; MIC50, MIC at which 50% of isolates are inhibited.

  • b Minor discrepancies, susceptible-dose dependant by one method but susceptible or resistant by the other; Major discrepancies, resistant by the test method but susceptible by the reference test; very major discrepancies, susceptible by the test method but resistant by the reference test.

  • c The value shown is the percentage of the time that a result of susceptible by the agar-based method correlated with a susceptible or susceptible-dose dependent result by the reference MD method.

  • d The value shown is the percentage of the time that a result of resistant by the agar-based method correlated with a result of resistance by the reference MD method.