TABLE 5.

Retention of the antistaphylococcal activity of various creams in cotton rat noses over time

Treatment, timea (h)% Reduction in CFUb
Control (no cream)0
Placebo cream, 430
Placebo cream, 2420
0.5% lysostaphin, 4 (∼150 μg)100
0.5% lysostaphin, 24 (∼150 μg)100
0.125% lysostaphin, 4 (∼37.5 μg)87
5% nisin, 2 (∼1,500 μg)35
  • a Time after instillation of cream when nose was excised and incubated with 103 CFU of exogenous S. aureus.

  • b Determined in relationship to the control sample. Mean of three samples.