TABLE 2.

S. aureus nasal colonization of cotton rats following various intranasal treatments

Nasal treatmentNo. of rats colonized/no. tested% EradicatedNo. of exptsCFU recovered/colonized naris
MeanMedian
Control (no treatment)a41/410105,2624,715
Placebo creamb
    3 doses23/23053,3722,010
    1 dose23/23056,3546,790
Lysostaphin, 110 μg in 10 μl of PBS, 2 dosesb6/93323,3032,012
0.5% lysostaphin cream (∼150 μg/dosec)b
    3 doses0/14100300
    1 dose5/71931185
0.125% lysostaphin cream (∼37.5 μg/dose)b
    3 doses9/20553672165
    1 dose8/102021,0061,071
  • a Control nares harvested between 4 and 8 days after bacterial instillation.

  • b Nares treated 4 to 7 days after bacterial instillation and harvested 24 h posttreatment

  • c Doses of cream were ∼30 μl/nose split equally between two nostrils.