Lysostaphin eradicates nasal colonization by S. aureus MBT 5040 in vivo within 4 h of treatment and not ex vivo due to antibiotic carryover

Treatment of rat noseaNo. of rats with nasal colonization/no. testedMean CFU recovered/nose
Control (buffer only)4/41,065
0.5% lysostaphin in buffer0/40
0.5% lysostaphin + proteinase K0/50
  • a Treated noses were excised 4 h posttreatment.